Astros vs Padres Predictions, Picks, Odds — 9-16

Houston Astros vs. San Diego Padres

Friday, Sept. 16, 10:10 p.m. ET

The Houston Astros (106-55) take on the San Diego Padres (88-70) on Friday, Sept. 16, at 10:10 p.m. ET at Petco Park in San Diego, Calif. The Astros clinched the AL West title on Tuesday with a 10-0 win over the Los Angeles Angels. They have won four straight games and are 15-5 in their last 20 games. The Padres are fighting for a wild-card spot. They are currently 3.5 games behind the Milwaukee Brewers for the third and final wild-card spot. The Padres have lost two straight games and are 7-13 in their last 20 games.

The Astros are the favorites in this matchup. They have a better record, a better offense, and a better pitching staff. The Padres will need to play their best game of the season if they want to win this game.

Here are the betting odds for the game, according to DraftKings Sportsbook:

- Astros: -155 - Padres: +135 - Over/Under: 7.5

Prediction: Astros 4, Padres 2

The Astros are the better team and they should win this game. They have a better offense, a better pitching staff, and they are playing with more confidence. The Padres will need to play their best game of the season if they want to win this game, but I don't think they will be able to do it. The Astros will win this game 4-2.